Artificial sweetener erythritol and cardiovascular event risk

The Nature article is for sale... and little info is available, but I did add it at the bottom regardless. . Some data they collected from blood samples was not cleared to be used for the research so that leaves them unable to release all of the data even if you pay for it. (That is my interpretation... anyone with more knowledge, please add a comment) The researches were looking for common underlying links in patients undergoing cardiac risk assessment when they discovered erythritol in much larger quantities in the blood than our bodies would normally make. They then began to study what effect it may have on the cardiovascular system.

Artificial sweeteners are often recommended by Doctors for obesity, Diabetes and are found in many kinds different foods and drinks labeled sugar-free such as diet soft drinks/candy/chocolate/baked goods/ cough drops /gum. These people are already at higher risk for major adverse cardiac events. (MACE)

Plus, it may be added to provide bulk... "Erythritol provides volume and texture, making Splenda Stevia easier to use." Also in Truvia. https://www.splenda.com/faqs/why-is-erythritol-an-ingredient-in-splenda-stevia-sweetener/

Erythritol can also be found in many keto reduced-sugar products as it is calorie free. https://www.cbsnews.com/news/artificial-sweetener-erythritol-linked-to-heart-attack-and-stroke-study-finds/

The Cleveland Clinic Media release:

Researchers studied over 4,000 people in the U.S. and Europe and found those with higher blood erythritol levels were at elevated risk of experiencing a major adverse cardiac event such as heart attack, stroke or death. They also examined the effects of adding erythritol to either whole blood or isolated platelets, which are cell fragments that clump together to stop bleeding and contribute to blood clots. Results revealed that erythritol made platelets easier to activate and form a clot. Pre-clinical studies confirmed ingestion of erythritol heightened clot formation. https://newsroom.clevelandclinic.org/2023/02/27/cleveland-clinic-study-finds-common-artificial-sweetener-linked-to-higher-rates-of-heart-attack-and-stroke/

“Sweeteners like erythritol, have rapidly increased in popularity in recent years but there needs to be more in-depth research into their long-term effects,” said senior author Stanley Hazen, M.D., Ph.D., chairman for the Department of Cardiovascular & Metabolic Sciences in Lerner Research Institute and co-section head of Preventive Cardiology at Cleveland Clinic. “Cardiovascular disease builds over time, and heart disease is the leading cause of death globally. We need to make sure the foods we eat aren’t hidden contributors.”

Artificial Sweetener Links to Higher Rates of Heart Attack and Stroke: https://www.nature.com/articles/s41591-023-02223-9

The researchers found other multiple polyol sweeteners in the samples, but none as prevalent as erythritol.

More study is needed... but the results of this has the [lucrative obesity/diet/circle jerk] low-and reduced-calorie food and beverage industry on edge. the may be right but only more studies will tell.

Robert Rankin, executive director of the Calorie Control Council, an international association representing the low- and reduced-calorie food and beverage industry, told CBS News the results are "contrary to decades of scientific research showing low- and no-calorie sweeteners like erythritol are safe, as evidenced by global regulatory permissions for their use in foods and beverages, and should not be extrapolated to the general population, as the participants in the intervention were already at increased risk for cardiovascular events." https://www.cbsnews.com/news/artificial-sweetener-erythritol-linked-to-heart-attack-and-stroke-study-finds/

Being Salient added a blurb with no URL and I complained about the presentation of the information so much the post was removed (By a mod or Salient) I felt obliged to add more info and URLs (none were included in the original post) as this may be a very important find for the future. Meanwhile... a lot of people will be checking labels no doubt.